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Shorter regimen supported by clinical trials for multidrug-resistant TB

Updated: 13 March 2019

A non-inferiority phase 3 trials has been done in 424 subjects having rifampin-resistant tuberculosis and are susceptible to aminoglycosides and fluoroquinolones. Random selection of subjects was done to impart either a long regimen of 20 months or short regimen of 9-11 months in line with WHO guidelines. It was concluded from the trial that short regimen was alike the long regimen in safety terms.

Clinical data has been released for STREAM Trial, a trial for multidrug-resistant tuberculosis.